AGTR1, angiotensin II receptor type 1, 185

N. diseases: 440; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027404
Disease: Narcolepsy
Narcolepsy 		0.100 GeneticVariation disease GWASDB Genome-wide association database developed in the Japanese Integrated Database Project. 19629137 2009
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.700 Biomarker disease GENOMICS_ENGLAND Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension. 25603901 2015
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.600 Biomarker disease GENOMICS_ENGLAND Molecular and clinical analysis of TRPC6 and AGTR1 genes in patients with pulmonary arterial hypertension. 25603901 2015
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C0266313
Disease: Allanson Pantzar McLeod syndrome
Allanson Pantzar McLeod syndrome 		0.700 GeneticVariation disease UNIPROT We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1. 16116425 2005
CUI: C0018801
Disease: Heart failure
Heart failure 		0.600 Therapeutic disease RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.600 Therapeutic disease RGD The protective effects of telmisartan and losartan in ADR-induced heart failure may be partially due to regulation of circulating Ang-(1-7) and myocardial AT(1)R expression. 21963897 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Chronic infusion of angiotensin receptor antagonists in the hypothalamic paraventricular nucleus prevents hypertension in a rat model of sleep apnea. 21040717 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Increased endothelial gene expression of angiotensin AT1A receptor in cyclosporine induced hypertensive rats. 8181542 1993
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Reduction of cold-induced hypertension by antisense oligodeoxynucleotides to angiotensinogen mRNA and AT1-receptor mRNA in brain and blood. 9622148 1998
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker group RGD Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. 21346625 2011
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.500 Biomarker phenotype RGD Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. 20042458 2010
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Biomarker disease RGD Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade. 12172324 2002
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.300 Biomarker disease RGD Angiotensin type 2 receptor antagonism confers renal protection in a rat model of progressive renal injury. 12089373 2002
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.300 Biomarker disease RGD Alterations in sarcoplasmic reticulum and angiotensin II type 1 receptor gene expression after myocardial infarction in rats. 9652322 1998
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.250 Biomarker phenotype RGD Differential responses to salt supplementation in adult male and female rat adrenal glands following intrauterine growth restriction. 21303825 2011
CUI: C0020545
Disease: Hypertension, Renovascular
Hypertension, Renovascular 		0.250 Biomarker disease RGD Positive feedback regulation of angiotensin II-AT1B receptor gene expression in rat adrenal glands. 9644212 1998
CUI: C0020545
Disease: Hypertension, Renovascular
Hypertension, Renovascular 		0.250 Biomarker disease RGD Effect of celecoxib on the antihypertensive effect of losartan in a rat model of renovascular hypertension. 21326341 2011
CUI: C0020545
Disease: Hypertension, Renovascular
Hypertension, Renovascular 		0.250 Biomarker disease RGD [Effects of RNA interference targeting angiotensin 1a receptor on the blood pressure and cardiac hypertrophy of rats with 2K1C hypertension]. 16796846 2006
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.230 Biomarker phenotype RGD Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts. 21367774 2011